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Home / Primary Antibodies / Monoclonal Antibodies

Anti-p16 (INK4a)

SKU : BHA15100202

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BioGenex Laboratories

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Mfr.No.	AM540-5M
Clonality	Monoclonal
Description	p16/INK4A is a tumor-suppressor protein member of the Ink4 family of CDK inhibitors. The abnormalities arising in genes controlling the G1 checkpoint can lead to escape from senescence and tumor development. The p16/INK4 binds to CDK4/6 or ternary complex and prevents the formation of cyclin D-bound CDK4/6 complex and prevents phosporylation of Rb family members, resulting in E2F1 binding and G1 cell cycle arrest, followed by inhibition of cell cycle progression. The expression of p16 INK4A is commonly associated with cellular senescence, disruption of the p16 INK4A gene is frequently associated with tumor developemt. Similarly it has been observed that p16/INK4A locus is deleted in a wide spectrum of tumors including melanoma, pancreatic adenocarcinoma, glioblastoma, certain leukemias, non-small cell lung cancer, cervical cancer, and bladder carcinoma
Host	Mouse
Isotype	IgG
Reactivity	Human
Species	Mouse

Clone No	G175-405
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:10-20

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AM540-5M	AM540-5M	6 mL	$404		Add to Cart
AM540-10M	AM540-10M	100 tests - i6000	$718		Add to Cart
AX540-50D	AX540-50D	50 tests - Xmatrx	$424		Add to Cart
AX540-YCD	AX540-YCD	160 tests - Xmatrx	$1237		Add to Cart
MU540-UC	MU540-UC	1ml Conc	$314		Add to Cart
MU540-5UC	MU540-5UC	0.5ml Conc	$220		Add to Cart

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