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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Multi-Drug Resistance Marker (P-Glycoprotein)

SKU : BHA15100154

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BioGenex Laboratories

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Mfr.No.	AM391-5M
Clonality	Monoclonal
Description	Multi-drug resistance marker (P-glycoprotein) is a cell membrane protein marker of 170 kDa molecular weight expressed by multidrug resistance gene, MDR-1 . Studies have shown that the P-glycoprotein is responsible for resistance to a broad range of chemotherapeutic agents. P-glycoprotein in association with an afflux pump that actively pumps out the from the cell, it leads to drug resistance to a variety of chemotherapeutic agents. P-glycoprotein is not exclusive to malignant cells, it is also found expressed on most normal tissues, indicating the key role for this protein is in normal secretion of physiological metabolites. Tumor cell lines with multi-drug resistance show prominent levels of P-glycoprotein. Studies have reported that cancer cells with weak drug resistant showed cytoplasmic immunoreactivity for P-glycoprotein, whereas in highly drug resistant cell lines, plasma membrane immunoreactivity was observed
Host	Mouse
Isotype	IgG1 Kappa
Reactivity	Human
Species	Mouse

Clone No	MDR88
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:20-50

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AM391-5M	AM391-5M	6 mL	$217		Add to Cart
AM391-10M	AM391-10M	100 tests - i6000	$390		Add to Cart
AX391-50D	AX391-50D	50 tests - Xmatrx	$229		Add to Cart
AX391-YCD	AX391-YCD	160 tests - Xmatrx	$679		Add to Cart
MU391-UC	MU391-UC	1ml Conc	$650		Add to Cart
MU391-5UC	MU391-5UC	0.5ml Conc	$455		Add to Cart

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