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Home / Primary Antibodies / Monoclonal Antibodies

ANTI -MSH2

SKU : BHA15100409

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BioGenex Laboratories

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Mfr.No.	AMA23-5M
Clonality	Monoclonal
Description	MSH2 is a protein involved in the mismatch repair process after DNA replication. It contains a DNA binding domain and two interaction domains, one for MSH3 or MSH6 and the other for MutL homologs. MSH2 can bind to MSH6 or to MSH3 to form the MutS alpha or the MutS beta complexes respectively. The mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also displays microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression
Host	Mouse
Isotype	IgG1 Kappa Light Chain
Reactivity	Human
Species	Mouse

Clone No	D-9
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:10-20

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AMA23-5M	AMA23-5M	6 mL	$370		Add to Cart
AMA23-10M	AMA23-10M	100 tests - i6000	$625		Add to Cart
AXA23-50D	AXA23-50D	50 tests - Xmatrx	$387		Add to Cart
AXA23-YCD	AXA23-YCD	160 tests - Xmatrx	$939		Add to Cart
MUA23-UC	MUA23-UC	1ml Conc	$616		Add to Cart
MUA23-5UC	MUA23-5UC	0.5ml Conc	$433		Add to Cart

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