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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Insulin

SKU : BHA15100015

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BioGenex Laboratories

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Mfr.No.	AM029-5M
Clonality	Monoclonal
Description	Insulin is a peptide hormone produced in the pancreas by the B cells of the islets of Langerhans. Its functional role is to promote glucose utilization, protein synthesis, and the formation and storage of neutral lipids. Lack of this hormone gives rise to diabetes mellitus. Insulin-producing B cells are one of at least seven different cell types within the islets. These pancreatic endocrine cells are present not only within the islets but also in small and variable numbers in extrainsular locations. They can be present either singly or in small clusters along the pancreatic ductular epithelium, as well as within the particular acinar elements. The development of specific antibodies to various polypeptide hormones have made IHC localization of these hormones the most sensitive and reliable means available for an accurate characterization of the function of islet cell tumors. Since many islet cell tumors are multihormonal in nature, classification of the tumor is based on the predominant hormone present. Tumors producing large amounts of insulin are referred to as insulinomas. Insulin producing B cells occupy a central position in the islet, constituting 60% to 80% of the islet cell population. Islet cell hyperplasia and/or multiple adenomas are present in approximately 10% of hyperinsulinism cases. Multiple insulin-producing tumors, hyperplastic islets, areas of nesidioblastosis, and cells budding from the ductular structures stain positive for insulin. This antibody recognizes the A chain loop of human insulin. Cross-reactivity with bovine, rat and mouse insulin has been observed.
Host	Mouse
Isotype	IgG1
Reactivity	Human
Species	Mouse

Clone No	HB125
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:50-100

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AM029-5M	AM029-5M	6 mL	$310		Add to Cart
AM029-10M	AM029-10M	100 tests - i6000	$552		Add to Cart
AX029-50D	AX029-50D	50 tests - Xmatrx	$327		Add to Cart
AX029-YCD	AX029-YCD	160 tests - Xmatrx	$883		Add to Cart
MU029-UC	MU029-UC	1ml Conc	$200		Add to Cart
MU029-5UC	MU029-5UC	0.5ml Conc	$140		Add to Cart

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