Cytokeratin 8 & 18 are present in various epithelia including that of the breast, thyroid, respiratory tract, and gastrointestinal tract. Anti-Cytokeratin 8 & 18 stains adenocarcinomas and most non-keratinizing squamous carcinomas, but does not stain keratinizing squamous carcinomas. Since Cytokeratin 18 is scarce in normal epidermis, Anti-Cytokeratin 8 & 18 is used to detect Paget cells in such samples. Cytokeratin 8 & 18 helps identify colorectal carcinoma metastases as it is more sensitive than genetic tests.
Host
Rabbit/Mouse
Isotype
Rabbit IgG/Mouse IgG1
Species
Human
Clone No
IHC559
Buffer
Tris Buffer pH7.6 with BSA, and sodium azide as preservative