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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Cytokeratin 17

SKU : BHA15100375

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BioGenex Laboratories

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Mfr.No.	AM981-5M
Clonality	Monoclonal
Description	Cytokeratin 17 is a type 1 keratin found in epidermal appendages and contains 432 amino acids. Cytokeratin 17 modulates the function of TNF-alpha in the specific context of hair cycling. This protein regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity) and is involved in tissue repair. Cytokeratin 17 also promotes cell proliferation and migration of cells therefore signaling its role in the expansion of tumor/cancerous cells (especially oral squamous cell carcinoma). In oral squamous cell carcinoma, KRT17 acts as a pathogenic keratin that facilitates tumor growth through the stimulation of multiple signaling pathways, highlighting the importance of KRT17 as a multifunctional promoter of tumorigenesis. Mutations in Cytokeratin 17 can result in hair loss and tumor growth in vivo. Furthermore, Cytokeratin 17 may also be useful in distinguishing carcinomas of the cervix from those of the colon and also from mesotheliomas. Through Immunohistochemistry staining, expression of Cytokeratin 17 is seen in the membrane and cytoplasm of squamous cell carcinomas.
Host	Mouse
Isotype	IgG2
Reactivity	Human
Species	Mouse

Clone No	KRT17/778
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:20-40

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AM981-5M	AM981-5M	6 mL	$204		Add to Cart
AM981-10M	AM981-10M	100 tests - i6000	$421		Add to Cart
AX981-50D	AX981-50D	50 tests - Xmatrx	$229		Add to Cart
AX981-YCD	AX981-YCD	160 tests - Xmatrx	$645		Add to Cart
MU981-UC	MU981-UC	1ml Conc	$339		Add to Cart
MU981-5UC	MU981-5UC	0.5ml Conc	$234		Add to Cart

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