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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Cystatin C/CST3 Antibody (monoclonal, 8H7)

SKU : BHA21002118

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Mfr.No.	M00961-3, M00961-3-10ug, M00961-3-Biotin, M00961-3-Cy3, M00961-3-Dylight488, M00961-3-Dylight550, M00961-3-Dylight594, M00961-3-FITC, M00961-3-HRP, M00961-3-APC, M00961-3-PE, M00961-3-iFluor647, M00961-3-carrier-free
Alternative Names	cystatin C
Background	Cystatin C or cystatin 3, a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cystatin C/CST3 Antibody Picoband® (monoclonal, 8H7) catalog # M00961-3. Tested in ELISA applications. This antibody reacts with Human.
Function	As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Host	Mouse
Immunogen Region	E. coli-derived human Cystatin C recombinant protein (Position: K31-A146).
Isotype	Mouse IgG1
Molecular Weight	15 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Nuclear factor 1 A-type; NF1-A; Nuclear factor 1/A; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/A; NF-I/A; NFI-A; TGGCA-binding protein; NFIA; KIAA1439
Tissue Specificity	Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P01034
Gene Id	1471
Gene Name	CST3
Clone No	Clone: 8H7
Subcellular Location	Nucleus

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA
Description	ELISA (Cap), 1-5ug/ml<br>

Reference	1. Abrahamson, M., Grubb, A. Increased body temperature accelerates aggregation of the leu68-to-gln mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy. Proc. Nat. Acad. Sci. 91: 1416-1420, 1994.<br /><br />2. Crawford, F. C., Freeman, M. J., Schinka, J. A., Abdullah, L. I., Gold, M., Hartman, R., Krivian, K., Morris, M. D., Richards, D., Duara, R., Anand, R., Mullan, M. J. A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease. Neurology 55: 763-768, 2000.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002118-1	M00961-3	-	100 ug	$370		Add to Cart
BHA21002118-2	M00961-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21002118-3	M00961-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002118-4	M00961-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002118-5	M00961-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002118-6	M00961-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002118-7	M00961-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002118-8	M00961-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21002118-9	M00961-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21002118-10	M00961-3-APC	APC	100 ug	$670		Add to Cart
BHA21002118-11	M00961-3-PE	PE	100 ug	$670		Add to Cart
BHA21002118-12	M00961-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002118-13	M00961-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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