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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Cofilin 2/CFL2 Antibody Picoband® (monoclonal, 8C13)

SKU : BHA21002261

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Mfr.No.	M04773, M04773-10ug, M04773-Biotin, M04773-Cy3, M04773-Dylight488, M04773-Dylight550, M04773-Dylight594, M04773-FITC, M04773-HRP, M04773-APC, M04773-PE, M04773-iFluor647, M04773-carrier-free
Alternative Names	cofilin 2
Background	Cofilin 2 (muscle), also known as CFL2, is a protein which in humans is encoded by the CFL2 gene. It is mapped to 14q12. This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. And this protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alteative splicing results in multiple transcript variants.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cofilin 2/CFL2 Antibody Picoband® (monoclonal, 8C13) catalog # M04773. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the m
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Cofilin 2/CFL2, identical to the related mouse sequence.
Isotype	Mouse IgG2b
Molecular Weight	19 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cofilin-2; Cofilin, muscle isoform; CFL2
Tissue Specificity	Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q9Y281
Gene Id	1073
Gene Name	CFL2
Clone No	Clone: 8C13
Subcellular Location	Cytoskeleton. Nucleus matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1. "Entrez Gene: CFL2 cofilin 2 (muscle)".<br /><br />2. Agrawal PB, Greenleaf RS, Tomczak KK, Lehtokari VL, Wallgren-Pettersson C, Wallefeld W, Laing NG, Darras BT, Maciver SK, Dormitzer PR, Beggs AH (January 2007). "Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2". Am. J. Hum. Genet. 80 (1): 1627.<br /><br />3. Gillett GT, Fox MF, Rowe PS, Casimir CM, Povey S (May 1996). "Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14". Ann. Hum. Genet. 60 (Pt 3): 20111.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002261-1	M04773	-	100 ug	$370		Add to Cart
BHA21002261-2	M04773-10ug	Sample	10 ug	$99		Add to Cart
BHA21002261-3	M04773-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002261-4	M04773-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002261-5	M04773-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002261-6	M04773-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002261-7	M04773-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002261-8	M04773-FITC	FITC	100 ug	$570		Add to Cart
BHA21002261-9	M04773-HRP	HRP	100 ug	$570		Add to Cart
BHA21002261-10	M04773-APC	APC	100 ug	$670		Add to Cart
BHA21002261-11	M04773-PE	PE	100 ug	$670		Add to Cart
BHA21002261-12	M04773-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002261-13	M04773-carrier-free	carrier-free	100 ug	$370		Add to Cart

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