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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CD22 Antibody Picoband® (monoclonal, 5E7)

SKU : BHA21002385

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Mfr.No.	M01572-2, M01572-2-10ug, M01572-2-Biotin, M01572-2-Cy3, M01572-2-Dylight488, M01572-2-Dylight550, M01572-2-Dylight594, M01572-2-FITC, M01572-2-HRP, M01572-2-APC, M01572-2-PE, M01572-2-iFluor647, M01572-2-carrier-free
Alternative Names	CD22 molecule
Background	CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. It is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering. The human CD22 gene is expressed specifically in B lymphocytes and likely has an important function in cell-cell interactions. The B cell coreceptor CD22 plays an important role in regulating signal transduction via the B cell Ag receptor. And CD22 is located within the band region q13.1 of chromosome 19.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CD22 Antibody Picoband® (monoclonal, 5E7) catalog # M01572-2. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be ma
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human CD22, different from the related mouse sequence by ten amino acids.
Isotype	Mouse IgG2b
Molecular Weight	140 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD22; SIGLEC2
Tissue Specificity	B-lymphocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.01mg NaN<sub>3</sub>.

Uniprot	P20273
Gene Id	933
Gene Name	CD22
Clone No	Clone: 5E7
Subcellular Location	Cell membrane; Single-pass type I membrane protein

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. John, B.; Herrin, B. R.; Raman, C.; Wang, Y.; Bobbitt, K. R.; Brody, B. A.; Justement, L. B. The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J. Immun. 170: 3534-3543, 2003. <br /><br />2. O'Keefe, T. L.; Williams, G. T.; Davies, S. L.; Neuberger, M. S. Hyperresponsive B cells in CD22-deficient mice. Science 274: 798-801, 1996.<br /><br />3. Wilson, G. L.; Najfeld, V.; Kozlow, E.; Menniger, J.; Ward, D.; Kehrl, J. H. Genomic structure and chromosomal mapping of the human CD22 gene. J. Immun. 150: 5013-5024, 1993.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002385-1	M01572-2	-	100 ug	$370		Add to Cart
BHA21002385-2	M01572-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002385-3	M01572-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002385-4	M01572-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002385-5	M01572-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002385-6	M01572-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002385-7	M01572-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002385-8	M01572-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002385-9	M01572-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002385-10	M01572-2-APC	APC	100 ug	$670		Add to Cart
BHA21002385-11	M01572-2-PE	PE	100 ug	$670		Add to Cart
BHA21002385-12	M01572-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002385-13	M01572-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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