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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Caveolin-1/CAV1 Antibody Picoband® (monoclonal, 12C7)

SKU : BHA21002115

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Mfr.No.	M00179-1, M00179-1-10ug, M00179-1-Biotin, M00179-1-Cy3, M00179-1-Dylight488, M00179-1-Dylight550, M00179-1-Dylight594, M00179-1-FITC, M00179-1-HRP, M00179-1-APC, M00179-1-PE, M00179-1-iFluor647, M00179-1-carrier-free
Alternative Names	caveolin 1, caveolae protein, 22kDa
Background	CAV1 ( Caveolin-1) is a protein that in humans is encoded by the CAV1 gene. The CAV1 gene is mapped to 7q31.2. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alteative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Caveolin-1/CAV1 Antibody Picoband® (monoclonal, 12C7) catalog # M00179-1. Tested in IF, IHC, IHC-F, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May act as a scaffolding protein within caveolar membranes. Interacts ly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its b
Host	Mouse
Immunogen Region	E.coli-derived human Caveolin-1 recombinant protein (Position: G4-I178). Human Caveolin-1 shares 95% and 94% amino acid (aa) sequence identity with mouse and rat Caveolin-1, respectively.
Isotype	Mouse IgG2a
Molecular Weight	22 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Caveolin-1; CAV1; CAV
Tissue Specificity	Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q03135
Gene Id	857
Gene Name	CAV1
Clone No	Clone: 12C7
Subcellular Location	Cell membrane. Peripheral membrane protein. Golgi apparatus membrane. Peripheral membrane protein. Trans-Golgi network. Caveola. Peripheral membrane protein. Membrane raft.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, IHC-F, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml<br> Immunofluorescence, 2ug/ml

Reference	1. Tahir, S. A., Yang, G., Ebara, S., Timme, T. L., Satoh, T., Li, L., Goltsov, A., Ittmann, M., Morrisett, J. D., Thompson, T. C.Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer.Cancer Res. 61: 3882-3885, 2001.<br /><br />2. Wang, X. M., Zhang, Y., Kim, H. P., Zhou, Z., Feghali-Bostwick, C. A., Liu, F., Ifedigbo, E., Xu, X., Oury, T. D., Kaminski, N., Choi, A. M. K.Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.J. Exp. Med. 203: 2895-2906, 2006.<br /><br />3. Yang, G., Truong, L. D., Timme, T. L., Ren, C., Wheeler, T. M., Park, S. H., Nasu, Y., Bangma, C. H., Kattan, M. W., Scardino, P. T., Thompson, T. C.Elevated expression of caveolin is associated with prostate and breast cancer.Clin. Cancer Res. 4: 1873-1880, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002115-1	M00179-1	-	100 ug	$370		Add to Cart
BHA21002115-2	M00179-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002115-3	M00179-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002115-4	M00179-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002115-5	M00179-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002115-6	M00179-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002115-7	M00179-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002115-8	M00179-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002115-9	M00179-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002115-10	M00179-1-APC	APC	100 ug	$670		Add to Cart
BHA21002115-11	M00179-1-PE	PE	100 ug	$670		Add to Cart
BHA21002115-12	M00179-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002115-13	M00179-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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