β-Catenin is a cytoplasmic protein with a dual role in cell-cell adhesion and gene expression. It is normally present in the submembranous regions of the cell, and nuclear accumulation of β-Catenin has been found to occur as a result of gene mutations. This accumulation is useful in identifying desmoid tumours (fibromatosis) in the abdomen and breast, and is therefore useful in differentiating other cell neoplasms in these regions.
Host
Mouse
Isotype
IgG1
Species
Human
Clone No
IHC516
Buffer
Tris Buffer pH7.6 with BSA, and sodium azide as preservative