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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Bax Protein

SKU : BHA15100126

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BioGenex Laboratories

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Mfr.No.	AR347-5R
Clonality	Polyclonal
Description	Apoptosis is a mechanism for programmed cell death, with morphological characteristics of chromatin condensation and crescent shaped deposits along the nuclear membrane. This type of cell death is distinct from accidental cell death or necrosis. Apoptosis is a normal and necessary process for tissue homeostasis that occurs in response to aging cells, DNA damage, thermal shock, or hormone signals. Tissues that continually regenerate require apoptosis in the area of terminal cells, and cell division and growth in the area of dividing cells. Two opposing but related groups of proteins have been identified that either promote or inhibit apoptosis. Bax protein is identified as promoter of apoptosis.The inhibitor proteins of apoptosis are known to form homodimers or heterodimers with the apoptosis promoter proteins. Some tissues express both bax protein and bcl- 2 protein in equal levels, but some cells express either type exclusively or dominantly. Cells displaying higher levels of bax relative to bcl-2 generally undergo apoptosis. The override of apoptotic control is suspected to cause or contribute to some forms of carcinogenesis. Since the proliferative rate of prostrate cancer is low, with less than 5% of cells typically undergoing division, the signals to override apoptosis may contribute to tumor growth. Studies of normal tissues demonstrate that the distribution of apoptotic regulator proteins correlates with the regenerative properties of the tissue studied. Epithelial cells of colon crypts show increases in bax expression and corresponding decreases in bcl-2 expression as cells progress from the base of crypts to the luminal surface. Likewise immune cells with improper antigen presentation not selected for clonal division show high expression of bax compared to cells undergoing clonal expansion. This antibody will detect the ? , ? , and ? isoforms of bax protein.
Host	Rabbit
Isotype	NA
Reactivity	Human
Species	Rabbit

Clone No	Polyclonal
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:10-20

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AR347-5R	AR347-5R	6 mL	$200		Add to Cart
AR347-10R	AR347-10R	100 tests - i6000	$349		Add to Cart
AW347-50D	AW347-50D	50 tests - Xmatrx	$208		Add to Cart
AW347-YCD	AW347-YCD	160 tests - Xmatrx	$608		Add to Cart
PU347-UP	PU347-UP	1ml Conc	$220		Add to Cart
PU347-5UP	PU347-5UP	0.5ml Conc	$157		Add to Cart

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