Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (UniProt)
Formulation
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Immunogen Region
A synthetic peptide specific to human Histone H2A (surrounding acetylated lysine 9) was used as the immunogen for the Histone H2A antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse
Reactivity
Human, Mouse
Recombinant
No
Subcellular Location
Nuclear
Antigen
Acetyl-Histone H2A
Uniprot
P04908
Clone No
DEB-8
Format
Purified
Purification
Affinity purified
Storage
Store the acetyl-Histone H2A Antibody (Lys9) at -20°C.
Applications
IHC-P, WB
Dilution
Western blot: 1:500-1:2000,Immunohistochemistry (FFPE): 1:500-1:1000