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Home / Biochemicals / Small Molecules

L-AP4

SKU : BHB21300199

A Potent and Selective Agonist of Group III mGluRs

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Mfr.No.	L-150, L-150_1 mg, L-150_10 mg, L-150_25 mg, L-150_5 mg, L-150_50 mg
Description	L-AP4 (#L-150) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C₄H₁₀NO₅P.
Synonyms	Synthetic
Background	L-AP4 is a synthetic, potent and selective agonist of group III metabotropic glutamate receptors (mGluR4 and mGluR6 through mGluR8). L-AP4 also depresses basal synaptic transmission in rat hippocampal slices with an IC50 of 3 uM in a dose dependent manner. Maximum depression of 74% is obtained at a concentration of 100 uM L-AP4. A concentration of 10 uM L-AP4 induces a depression of 59% and when the mGluR antagonist MCCG is added it shows little or no effect. In contrary, the mGluR antagonists MPPG and MTPG are effective L-AP4 antagonists1.L-AP4-sensitive neuronal glutamatergic pathways include synapses of the mossy-fiber/ CA3 projection synapses of pyramidal cell projecting from the lateral olfactory tract to the pyriform cortex and synaptic contacts in the basolateral amygdala. It has also been suggested that L-AP4 sensitive receptors are important for memory and learning and might be implicated in the pathogenesis of Alzheimer's disease2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-100 uM.
Reconstitution	Up to 25 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	23052-81-5
Molecular Weight	183.1
Solubility	Up to 25 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	mGluR4, 6, 7, 8
Activity	L-AP4 is a group III mGluR specific agonist. Reversibly depresses basal synaptic transmission in rat hippocampal slices (IC50 = 3 uM)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2S)-2-amino-4-phosphonobutanoic acid.

Purity	>97% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Bushell, T.J. et al. (1996) Br. J. Pharmacol. 117, 1457. Thomsen, C. (1997) Gen. Pharmacol. 29, 151. Bushell, T.J. et al. (1996) Br. J. Pharmacol. 117, 1457. Thomsen, C. (1997) Gen. Pharmacol. 29, 151.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300199-1	L-150_1 mg	1 mg	$145		Add to Cart
BHB21300199-2	L-150_10 mg	10 mg	$358		Add to Cart
BHB21300199-3	L-150_25 mg	25 mg	$714		Add to Cart
BHB21300199-4	L-150_5 mg	5 mg	$264		Add to Cart
BHB21300199-5	L-150_50 mg	50 mg	$1059		Add to Cart

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