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Home / Primary Antibodies / Monoclonal Antibodies

KDEL Receptor Antibody, Clone KR-10 (SMC-129)

BHA11900400
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Email
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Antigen KDEL Receptor
Swissprot P33946
Accession Number NP_001069963.1
Gene Id 618184
Target KDEL Receptor
Clone No KR-10
Research Area Cell Signaling, Tags and Cell Markers, Organelle Markers, Chaperone Proteins, Protein Trafficking
Buffer PBS pH7.2, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). However, variation on KDEL does occur and other sequences can also give rise to endoplasmic reticulum retention (6). There are three KDEL receptors in mammalian cells, all have a very high degree of sequence identity; and all are located within the cis-Golgi and its intermediate compartments (4).
In terms of function, KDEL receptors interact with GAP (GTPase-activating protein) of ARF1, which is involved in COPI dependent vesicle transport, and the KDEL receptor may also be responsible for the recruitment of this ARF1 to membranes which can then aid in the regulation of vesicle budding (3). It is also important to note that the KDEL receptor exhibits extensive sequence identity o yeast protein Erd2p, which is a receptor for the yeast ER retention signal (4, 5).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~25kDa.
Storage -20ºC
Storage Buffer PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP
Dilution WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Whiteman P., and Handford P.A. (2003) Hum Mol Genet 12(7): 727-737.

2. Forthoffer N., et al. (2002) J Bioenerg Biomemb 34(3): 209-219.

3. Aoe T., et al. (1997) EMBO J. 16: 7305-7316.

4. Tang B.L., Wong S.H, Qi X.L. Low S.H., and Hong W. (1993) J. Cell Biol. 120: 325-328.

5. Lewis M.J. and Pelham H.R. (1990) Nature 348: 162-163.

6. Spurger L. (2002). Endoplasmic reticulum: Structure and function. University of Texas Medical Branch. Retrieved September 13, 2006, from http://cellbio.utmb.edu/cellbio/rer1.htm
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11900400-1 SMC-129D Unconjugated 100 ug $321
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BHA11900400-2 SMC-129D-A390 ATTO 390 100 ug $376
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BHA11900400-3 SMC-129D-A488 ATTO 488 100 ug $374
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BHA11900400-4 SMC-129D-A594 ATTO 594 100 ug $374
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BHA11900400-5 SMC-129D-APC APC 100 ug $373
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BHA11900400-6 SMC-129D-BI Biotin 100 ug $369
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BHA11900400-7 SMC-129D-FITC FITC 100 ug $365
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BHA11900400-8 SMC-129D-HRP HRP 100 ug $360
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BHA11900400-9 SMC-129D-PCP PerCP 100 ug $373
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BHA11900400-10 SMC-129D-RPE RPE 100 ug $370
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BHA11900400-11 SMC-129S Unconjugated 12 ug $45
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