Inhibitor of kappaB kinase beta Adenovirus (Ad-IKKb)

Mfr.No.	1487
Description	The IkB kinases, IKK(alpha) (previously designated CHUK) and IKK(beta), are members of the helix-loop-helix, leucine zipper family of interacting proteins. IKK(alpha) specifically phosphorylates IkB(alpha) on the sites, serines 32 and 36, to trigger its degradation. The IKK complex appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKK(alpha) is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation. The functional IKK complex contains three subunits, IKK(alpha), IKK(beta) and IKK(gamma) (also designated NEMO, for NFkB essential modulator), and each appear to make essential contributions to IkB phosphorylation. TANK binding kinase (TBK1), also designated T2K, is an IKK-related kinase that complexes with TRAF2 and TANK in the NF?B activation pathway. IKK-i is an IKK-related serine/threonine kinase that is expressed in immune cells and is inducible by LPS, TNF(alpha), IL-1 and IL-6. Overexpression of IKK-i results in IkB(alpha) phosphorylation and NFkB activation.
Categories	Adenovirus, Over-Expression
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Gene expression
Promoter	CMV (ubiquitous)
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3)
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	IKKb
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Storage	-80C
Shipping	Dry Ice

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600182	1487	200 µL	$475		Add to Cart