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Home / Primary Antibodies / IHC Antibodies

TYK2 Antibody

BHA10557332
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Email
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Antigen TYK2
Target Details This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Uniprot P29597
Database Links

HGNC:12440

OMIM:176941

KEGG:hsa:7297

STRING:9606.ENSP00000264818

UniGene:Hs.75516
Function Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Pathway Jak-STAT signaling pathway Necroptosis NOD-like receptor signaling pathway Osteoclast differentiation Th1 and Th2 cell differentiation Th17 cell differentiation
Protein Families Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Tissue Specificity Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format liquid
Purification Affinity purification
Purity Affinity purification
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Applications ELISA, WB, IHC
Description ELISA ; WB ; IHC, WB ; ELISA ; IHC
Dilution

WB1:500-1:2000
IHC1:50-1:200
Tested Application ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
SKU Supplier No. Size Your price Quantity
BHA10557332 CSB-PA025391KA01HU 100μl $387.33
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