JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.
Loding Loading ....
Home / Primary Antibodies / IHC Antibodies

TAP2 Antibody

BHA10557238
Contact us to order
Tel
+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
Request More Infos
Order Now

Credit card payments now incur a 3% fee.

Contact us to order
Tel
+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
Ask Merchant
Request More Infos
Sample Request
Antigen TAP2
Rgd 3818
Target Details The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. This protein is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
Uniprot Q03519
Gene Id 6891
Database Links

HGNC:44

OMIM:170261

KEGG:hsa:6891

STRING:9606.ENSP00000364034

UniGene:Hs.502
Function Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Pathway Antigen processing and presentation
Protein Families ABC transporter superfamily, ABCB family, MHC peptide exporter (TC 3.A.1.209) subfamily
Weight 72,003 Da
Buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format liquid
Purification Affinity purification
Purity Affinity purification
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Applications ELISA, WB, IHC
Description ELISA ; WB ; IHC, WB ; ELISA ; IHC
Dilution

WB1:500-1:2000
IHC1:50-1:200
Tested Application ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
SKU Supplier No. Size Your price Quantity
BHA10557238 CSB-PA023121KA01HU 100μl $387.33
Add to Cart