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Home / Primary Antibodies / IHC Antibodies

STAT2 (Ab-690) Antibody

SKU : BHA10559072

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA974482
Alternative Names	P113; ISGF-3; STAT113
Categories	Primary Antibodies
Clonality	polyclonal
Description	STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus.Fu, X. et al. (1992) Biochemistry 89, 7840-7843.Park, C. et al. (2000) Immunity 13, 795-804.Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964.Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.
Host	Rabbit
Immunogen	Peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2.
Involvement In Disease	Immunodeficiency 44 (IMD44)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Fu, X. et al. (1992) Biochemistry 89, 7840-7843. Park, C. et al. (2000) Immunity 13, 795-804. Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964. Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total STAT2 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P52630
Database Links	HGNC:11363 OMIM:600556 KEGG:hsa:6773 STRING:9606.ENSP00000315768 UniGene:Hs.530595
Function	Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state
Pathway	Chemokine signaling pathway Jak-STAT signaling pathway Necroptosis NOD-like receptor signaling pathway Osteoclast differentiation
Protein Families	Transcription factor STAT family

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559072	CSB-PA974482	100ul	$297		Add to Cart

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