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Home / Primary Antibodies / IHC Antibodies

SMAD2 (Ab-220) Antibody

SKU : BHA10559112

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA594584
Alternative Names	JV18-1; MADH2; MADR2; Mad-related protein 2; Mothers against DPP homolog 2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.Riggins G.J., Nat. Genet. 13:347-349(1996).Zhang Y., Nature 383:168-172(1996).Eppert K., Cell 86:543-552(1996).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Smad2 around the phosphorylation site of threonine 220 (P-E-T(p)-P-P).
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Riggins G.J., Nat. Genet. 13:347-349(1996). Zhang Y., Nature 383:168-172(1996). Eppert K., Cell 86:543-552(1996).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Smad2 protein
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q15796
Database Links	HGNC:6768 OMIM:601366 KEGG:hsa:4087 STRING:9606.ENSP00000262160 UniGene:Hs.12253
Function	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Pathway	Hippo signaling pathway TGF-beta signaling pathway Adherens junction Cell cycle Cellular senescence Signaling pathways regulating pluripotency of stem cells Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Apelin signaling pathway FoxO signaling pathway Endocytosis
Protein Families	Dwarfin/SMAD family
Tissue Specificity	Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559112	CSB-PA594584	100ul	$297		Add to Cart

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