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Home / Primary Antibodies / IHC Antibodies

SMAD1 (Ab-187) Antibody

SKU : BHA10559111

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA927298
Alternative Names	BSP-1; BSP1; Dwarfin-A; Dwf-A; JV4-1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.Riggins G.J., Nat. Genet. 13:347-349(1996).Liu F., Nature 381:620-623(1996).Hoodless P.A., Cell 85:489-500(1996)
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Smad1 around the phosphorylation site of serine 187 (P-H-S(p)-P-N).
Involvement In Disease	SMAD1 variants may be associated with susceptibility to pulmonary hypertension, a disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Riggins G.J., Nat. Genet. 13:347-349(1996). Liu F., Nature 381:620-623(1996). Hoodless P.A., Cell 85:489-500(1996)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Smad1 protein
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q15797
Database Links	HGNC:6767 OMIM:601595 KEGG:hsa:4086 STRING:9606.ENSP00000305769 UniGene:Hs.604588
Function	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
Pathway	Hippo signaling pathway TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells
Protein Families	Dwarfin/SMAD family
Tissue Specificity	Ubiquitous. Highest expression seen in the heart and skeletal muscle.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559111	CSB-PA927298	100ul	$297		Add to Cart

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