SensiStainTM Anti-PAX-8 Antibody is in ready-to-use format. PAX-8 belongs to the paired box (PAX) family of transcription factors which play an important role in early development such as with thyroid follicular cells and the expression of thyroid-specific genes; however mutations in the PAX8 gene is found to be associated with thyroid follicular carcinomas. PAX-8 is also found to be expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes. It has been found to be as useful marker for renal epithelial tumors, ovarian cancer and for differential diagnoses in lung and neck tumors. Anti-PAX-8 can be used in conjunction with other markers such as uroplakin, mammaglobin and TTF-1 to determine the primary sites of invasive micropapilary carcinomas of ovary.
Formulation
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Immunogen
Recombinant Protein
Immunogen Region
Recombinant Protein
Isotype
IgG
Raised In
Rabbit
Shipping Condition
Ice packs
Species Reactivity
Human
Specificity
PAX-8
Note
1:50-1:200
Clone No
IHC048
Purity
Purified
Storage
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.