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Home / Primary Antibodies / IHC Antibodies

SCN11A Antibody

SKU : BHA10559598

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA961122
Alternative Names	NaN; SNS-2; NAV1.9; SCN12A
Categories	Primary Antibodies
Clonality	polyclonal
Description	Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
Host	Rabbit
Immunogen	Synthetic peptide corresponding to a region derived from internal residues of Human sodium channel, voltage-gated, type XI, alpha subunit
Involvement In Disease	Neuropathy, hereditary sensory and autonomic, 7 (HSAN7); Episodic pain syndrome, familial, 3 (FEPS3)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SCN1A/2A/3A/4A/5A/8A/9A/10A/11A/12A protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein

Uniprot	Q9UI33
Database Links	HGNC:10583 OMIM:604385 KEGG:hsa:11280 STRING:9606.ENSP00000307599 UniGene:Hs.591657
Function	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Protein Families	Sodium channel (TC 1.A.1.10) family, Nav1.9/SCN11A subfamily
Tissue Specificity	Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.

Buffer	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Form	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Format	liquid
Purification	Antigen Affinity Purified
Purity	Antigen Affinity Purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559598	CSB-PA961122	100ul	$297		Add to Cart

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