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Home / Primary Antibodies / IHC Antibodies

S100A1 Antibody

SKU : BHA10559910

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA224994
Alternative Names	S100-ALPHA ; S100 CALCIUM-BINDING PROTEIN A1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.Patrick Most, J. Biol. Chem., Nov 2003; 278: 48404 - 48412. Miki Okada, J. Biol. Chem., Feb 2004; 279: 4221 - 4233. Melanie Boerries, Mol. Cell. Biol., Jun 2007; 27: 4365 - 4373. Patrick Most, J. Clin. Invest., Dec 2004; 114: 1550 - 1563.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human S100 A1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. Patrick Most, J. Biol. Chem., Nov 2003; 278: 48404 - 48412. Miki Okada, J. Biol. Chem., Feb 2004; 279: 4221 - 4233. Melanie Boerries, Mol. Cell. Biol., Jun 2007; 27: 4365 - 4373. Patrick Most, J. Clin. Invest., Dec 2004; 114: 1550 - 1563.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total S100 A1 protein.
Subcellular Location	Cytoplasm

Uniprot	P23297
Database Links	HGNC:10486 OMIM:176940 KEGG:hsa:6271 STRING:9606.ENSP00000292169 UniGene:Hs.515715
Function	Probably acts as a Ca(2+) signal transducer
Protein Families	S-100 family
Tissue Specificity	Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559910	CSB-PA224994	100ul	$297		Add to Cart

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