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Home / Primary Antibodies / IHC Antibodies

RRAD Antibody

SKU : BHA10559877

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA233809
Alternative Names	GTP-binding protein RAD; RAD; RAD1; RAS associated with diabetes;
Categories	Primary Antibodies
Clonality	polyclonal
Description	May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane By similarity. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.Reynet C., Science 262:1441-1444(1993).The MGC Project Team; Genome Res. 14:2121-2127(2004).Moyers J.S., J. Biol. Chem. 272:11832-11839(1997).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human RAD.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane By similarity. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. Reynet C., Science 262:1441-1444(1993). The MGC Project Team; Genome Res. 14:2121-2127(2004). Moyers J.S., J. Biol. Chem. 272:11832-11839(1997).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total RAD protein.
Subcellular Location	Cell membrane

Uniprot	P55042
Database Links	HGNC:10446 OMIM:179503 KEGG:hsa:6236 STRING:9606.ENSP00000299759 UniGene:Hs.1027
Function	May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Protein Families	Small GTPase superfamily, RGK family
Tissue Specificity	Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559877	CSB-PA233809	100ul	$297		Add to Cart

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