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Home / Primary Antibodies / IHC Antibodies

RBM5 Antibody

SKU : BHA10559304

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA239401
Alternative Names	G15; H37; LUCA15; RMB5; RNA binding motif protein 5
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.Bader S., Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.Timmer T., Genomics 60:238-240(1999).Oh J.J., Nucleic Acids Res. 27:4008-4017(1999).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human RBM5.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. Bader S., Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. Timmer T., Genomics 60:238-240(1999). Oh J.J., Nucleic Acids Res. 27:4008-4017(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total RBM5 protein.
Subcellular Location	Nucleus

Uniprot	P52756
Database Links	HGNC:9902 OMIM:606884 KEGG:hsa:10181 STRING:9606.ENSP00000343054 UniGene:Hs.439480
Function	Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Protein Families	RBM5/RBM10 family
Tissue Specificity	Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559304	CSB-PA239401	100ul	$297		Add to Cart

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