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Home / Primary Antibodies / IHC Antibodies

PTGS1 Antibody

SKU : BHA10559718

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA164506
Alternative Names	COX3; PCOX1; CYCLOOXYGENASE 1; PARTIAL COX1 PROTEINS; PGHS1 CYCLOOXYGENASE 3
Categories	Primary Antibodies
Clonality	polyclonal
Description	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.Lawrence M. Szewczuk, J. Biol. Chem., May 2004; 279: 22727 - 22737.Syed R. Baber, Am J Physiol Heart Circ Physiol, Oct 2005; 289: H1476 - H1487.Subhashini Chandrasekharan, J. Lipid Res., Dec 2005; 46: 2636 - 2648.K. Trent Moreland, J. Pharmacol. Exp. T
Host	Rabbit
Immunogen	Synthesized peptide derived from Human COX1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. Lawrence M. Szewczuk, J. Biol. Chem., May 2004; 279: 22727 - 22737. Syed R. Baber, Am J Physiol Heart Circ Physiol, Oct 2005; 289: H1476 - H1487. Subhashini Chandrasekharan, J. Lipid Res., Dec 2005; 46: 2636 - 2648. K. Trent Moreland, J. Pharmacol. Exp. T
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total COX1 protein.
Subcellular Location	Microsome membrane, Peripheral membrane protein, Endoplasmic reticulum membrane, Peripheral membrane protein

Uniprot	P23219
Database Links	HGNC:9604 OMIM:176805 KEGG:hsa:5742 STRING:9606.ENSP00000354612 UniGene:Hs.201978
Function	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Protein Families	Prostaglandin G/H synthase family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559718	CSB-PA164506	100ul	$297		Add to Cart

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