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Home / Primary Antibodies / IHC Antibodies

POLH Antibody

SKU : BHA10557281

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA018315KA01HU
Alternative Names	POLH; FLJ16395; FLJ21978; RAD30; RAD30A; XP-V; XPV
Categories	Primary Antibodies
Description	This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.
Hgnc	9181
Host	Rabbit
Immunogen	Recombinant protein of human POLH
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	Xeroderma pigmentosum variant type (XPV)
Isotype	IgG
Mgi	1891457
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Nucleus

Rgd	1309893
Target Details	This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.
Uniprot	Q9Y253
Database Links	HGNC:9181 OMIM:278750 KEGG:hsa:5429 STRING:9606.ENSP00000361310 UniGene:Hs.655467
Function	DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS)
Protein Families	DNA polymerase type-Y family

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557281	CSB-PA018315KA01HU	100μl	$387.33		Add to Cart

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