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Home / Primary Antibodies / IHC Antibodies

POLB Antibody

SKU : BHA10559176

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA910465
Alternative Names	DNA polymerase beta; EC 2.7.7.7; EC 4.2.99;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.Hiroyuki Matsumoto, Plant Cell Physiol., Nov 1981; 22: 1317 - 1324.L.K. Karagyozov, Nucleic Acids Res., Jun 1978; 5: 1907 - 1917.F Costanzo, J. Virol., Mar 1977; 21: 996 - 1001.AJ Faber, Eur. J. Biochem., Nov 1981; 120: 357.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human DNA Polymerase β.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Hiroyuki Matsumoto, Plant Cell Physiol., Nov 1981; 22: 1317 - 1324. L.K. Karagyozov, Nucleic Acids Res., Jun 1978; 5: 1907 - 1917. F Costanzo, J. Virol., Mar 1977; 21: 996 - 1001. AJ Faber, Eur. J. Biochem., Nov 1981; 120: 357.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total DNA Polymerase β protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	P06746
Database Links	HGNC:9174 OMIM:174760 KEGG:hsa:5423 STRING:9606.ENSP00000265421 UniGene:Hs.654484
Function	Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
Pathway	DNA repair pathway
Protein Families	DNA polymerase type-X family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559176	CSB-PA910465	100ul	$297		Add to Cart

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