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Home / Primary Antibodies / IHC Antibodies

PMEPA1 Antibody

SKU : BHA10559838

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA172006
Alternative Names	Transmembrane prostate androgen-induced protein; Solid tumor-associated 1 protein; TMEPAI; PMEPA1; STAG1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.Xu L.L., Genomics 66:257-263(2000).Rae F.K., Mol. Carcinog. 32:44-53(2001).Deloukas P., Nature 414:865-871(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TMEPA.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. Xu L.L., Genomics 66:257-263(2000). Rae F.K., Mol. Carcinog. 32:44-53(2001). Deloukas P., Nature 414:865-871(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TMEPA protein.
Subcellular Location	Early endosome membrane, Single-pass membrane protein, Golgi apparatus membrane, Single-pass membrane protein

Uniprot	Q969W9
Database Links	HGNC:14107 OMIM:606564 KEGG:hsa:56937 STRING:9606.ENSP00000345826 UniGene:Hs.517155
Function	Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal
Protein Families	PMEPA1 family
Tissue Specificity	Highest expression in prostate. Also expressed in ovary.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559838	CSB-PA172006	100ul	$297		Add to Cart

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