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Home / Primary Antibodies / IHC Antibodies

PLCG1 Antibody

SKU : BHA10557377

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA889574
Alternative Names	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1, EC 3.1.4.11, PLC-148, PLC-II, PLC-gamma1, PLC1, PLCG-1, Phospholipase C-gamma-1
Categories	Primary Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene."
Host	Rabbit
Immunogen	A synthesized peptide derived from Human PLCG1
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. "
Species	Homo Sapiens (Human)
Specificity	PLCG1 Antibody detects endogenous levels of total PLCG1
Subcellular Location	Cell projection, lamellipodium, Cell projection, ruffle

Uniprot	P19174
Database Links	HGNC:9065 OMIM:172420 KEGG:hsa:5335 STRING:9606.ENSP00000244007 UniGene:Hs.268177
Function	Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Pathway	Calcium signaling pathway ErbB signaling pathway HIF-1 signaling pathway VEGF signaling pathway NF-kappa B signaling pathway MAPK Erk pathway Ras signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Oxidative Phosphorylation Phosphatidylinositol signaling system Phospholipase D signaling pathway Rap1 signaling pathway Neurotrophin signaling pathway

Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Form	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Format	liquid
Purification	Antigen Affinity Purified
Purity	Antigen Affinity Purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557377	CSB-PA889574	100ul	$295		Add to Cart

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