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Home / Primary Antibodies / IHC Antibodies

Piwil1 Antibody

SKU : BHA10557345

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA018045KA01HU
Alternative Names	Piwil1; Miwi; PIWIL1
Categories	Primary Antibodies
Description	The Drosophila piwi gene was identified as being required for the self-renewal of germline stem cells. Piwi homologs are well conserved among various species including Arabidopsis, C. elegans, and Homo sapiens. Both Miwi and Mili proteins are mouse homologs of Piwi and contain a C-terminal Piwi domain. Miwi and Mili bind to Piwi-interacting RNAs (piRNAs) in male germ cells and are essential for spermatogenesis in mice.
Host	Rabbit
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Isotype	IgG
Raised In	Rabbit
Reactivity	Mouse, Rat
Regulatory	RUO
Relevance	The Drosophila piwi gene was identified as being required for the self-renewal of germline stem cells. Piwi homologs are well conserved among various species including Arabidopsis, C. elegans, and Homo sapiens. Both Miwi and Mili proteins are mouse homologs of Piwi and contain a C-terminal Piwi domain. Miwi and Mili bind to Piwi-interacting RNAs (piRNAs) in male germ cells and are essential for spermatogenesis in mice.
Size	100μl(100μg)
Species	Mus Musculus (Mouse)
Subcellular Location	Cytoplasm

Target Details	This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.
Uniprot	Q9JMB7
Database Links	KEGG:mmu:57749 STRING:10090.ENSMUSP00000083222 UniGene:Mm.272720
Function	Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity
Protein Families	Argonaute family, Piwi subfamily
Tissue Specificity	Expressed in brain. Expressed in testis, specifically in spermatocytes (at protein level). Only detected in germ lineage cells of adult testis. Expressed in male gonads 2 weeks after birth at the initiation of spermatogenesis, but not expressed in female

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC, IF, IP

Description

ELISA ; WB ; IHC ; IF ; IP, IHC ; IF ; IP ; WB ; ELISA

Dilution

WB	1:500-1:2000
IHC	1:50-1:200
IF	1:20-1:100
IP	1:20-1:100

Tested Application

ELISA,WB,IHC,IF,IP;WB:1:500-1:2000,IHC:1:50-1:200,IF:1:20-1:100,IP:1:20-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunoprecipitation (IP) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557345	CSB-PA018045KA01HU	100μl	$387.33		Add to Cart

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