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Home / Primary Antibodies / IHC Antibodies

Phospho-NR4A1 (Ser351) Antibody

SKU : BHA10560175

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA198130
Alternative Names	NGFIB; GFRP1; HMR; NR4A1; NAK1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.Nakai A., Mol. Endocrinol. 4:1438-1443(1990).Chang C., J. Steroid Biochem. 34:391-395(1989).Bondy G.P., Cell Growth Differ. 2:203-208(1991)
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine351(L-P-S(p)-K-P) derived from Human Nuclear Receptor NR4A1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Nakai A., Mol. Endocrinol. 4:1438-1443(1990). Chang C., J. Steroid Biochem. 34:391-395(1989). Bondy G.P., Cell Growth Differ. 2:203-208(1991)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Nuclear Receptor NR4A1 only when phosphorylated at serine 351
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P22736
Database Links	HGNC:7980 OMIM:139139 KEGG:hsa:3164 STRING:9606.ENSP00000353427 UniGene:Hs.524430
Function	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.
Pathway	MAPK signaling pathway PI3K-Akt signaling pathway
Protein Families	Nuclear hormone receptor family, NR4 subfamily
Tissue Specificity	Fetal muscle and adult liver, brain and thyroid.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560175	CSB-PA198130	100ul	$360		Add to Cart

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