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Home / Primary Antibodies / IHC Antibodies

Phospho-MEF2C (Ser396) Antibody

SKU : BHA10560484

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA953903
Alternative Names	Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C; Similar to MADS box transcription enhancer factor 2 polypeptide C;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	MEF2C transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described. Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993).Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 396(P-V-S(p)-P-P) derived from Human MEF2C.
Involvement In Disease	Mental retardation, autosomal dominant 20 (MRD20)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	MEF2C transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described. Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993). McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993). Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of MEF2C only when phosphorylated at serine 396.
Subcellular Location	Nucleus, Cytoplasm, sarcoplasm

Uniprot	Q06413
Database Links	HGNC:6996 OMIM:600662 KEGG:hsa:4208 UniGene:Hs.649965
Function	Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Pathway	MAPK signaling pathway Apelin signaling pathway cGMP-PKG signaling pathway
Protein Families	MEF2 family
Tissue Specificity	Expressed in brain and skeletal muscle.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560484	CSB-PA953903	100ul	$360		Add to Cart

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