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Home / Primary Antibodies / IHC Antibodies

Phospho-INSR (T1375) Antibody

BHA10541933
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Contact us to order
Tel
+1 866.986.9598
Email
orders@biohippo.com
Get a Quote
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Uniprot P06213
Database Links

HGNC:6091

OMIM:125853

KEGG:hsa:3643

STRING:9606.ENSP00000303830

UniGene:Hs.465744
Function Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways
Pathway HIF-1 signaling pathway MAPK signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Adherens junction Ras signaling pathway AMPK signaling cGMP-PKG signaling pathway FoxO signaling pathway Insulin signaling pathway Phospholipase D signaling pathway Rap1 signaling pathway
Protein Families Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vasc
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, IHC, ELISA
Description WB ; IHC ; ELISA, WB ; ELISA ; IHC
Dilution

WB1:500-1:2000
IHC1:100-1:300
ELISA1/5000
Tested Application WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000
Datasheet
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10541933 CSB-PA011224 100ug $167
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BHA10541933 CSB-PA011224 50ug $100
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