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Home / Primary Antibodies / IHC Antibodies

Phospho-GAB2 (Ser623) Antibody

SKU : BHA10560482

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA108598
Alternative Names	pp100; KIAA0571 ; GRB2-associated binder 2;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.Nishida K., Blood 93:1809-1816(1999).Nagase T., DNA Res. 5:31-39(1998).Taylor T.D., Nature 440:497-500(2006).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 623(P-S-S(p)-P-S) derived from Human Gab2 .
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. Nishida K., Blood 93:1809-1816(1999). Nagase T., DNA Res. 5:31-39(1998). Taylor T.D., Nature 440:497-500(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Gab2 only when phosphorylated at serine 623.
Subcellular Location	Cytoplasm, Cell membrane

Uniprot	Q9UQC2
Database Links	HGNC:14458 OMIM:606203 KEGG:hsa:9846 STRING:9606.ENSP00000354952 UniGene:Hs.429434
Function	Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Pathway	Ras signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Osteoclast differentiation Phospholipase D signaling pathway Sphingolipid signaling pathway
Protein Families	GAB family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560482	CSB-PA108598	100ul	$360		Add to Cart

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