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Home / Primary Antibodies / IHC Antibodies

Phospho-BLM (Thr99) Antibody

SKU : BHA10560452

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA188391
Alternative Names	RECQ2; RECQL3; type 2; EC 3.6.1; RecQ protein-like 3
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).Ellis N.A., Cell 83:655-666(1995).Karow J.K., J. Biol. Chem. 272:30611-30614(1997).Pichierri P., EMBO J. 23:3154-3163(2004).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 99 (Q-E-T(p)-Q-R) derived from Human Bloom Syndrome.
Involvement In Disease	Bloom syndrome (BLM)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). Ellis N.A., Cell 83:655-666(1995). Karow J.K., J. Biol. Chem. 272:30611-30614(1997). Pichierri P., EMBO J. 23:3154-3163(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Bloom Syndrome Protein only when phosphorylated at threonine 99.
Subcellular Location	Nucleus

Uniprot	P54132
Database Links	HGNC:1058 OMIM:210900 KEGG:hsa:641 STRING:9606.ENSP00000347232 UniGene:Hs.725208
Function	ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction
Protein Families	Helicase family, RecQ subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560452	CSB-PA188391	100ul	$360		Add to Cart

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