Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.Sarah M. Mense, Toxicol. Sci., Sep 2006; 93: 125 - 135.Gunter Schmidtke, J. Biol. Chem., Jul 2006; 281: 20045 - 20054.sKunikazu Tanji, Am. J. Pathol., Aug 2006; 169: 553 - 565.Miguel Ramalho-Santos, Science, Oct 2002; 298: 597.
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human NYREN18.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
Sarah M. Mense, Toxicol. Sci., Sep 2006; 93: 125 - 135. Gunter Schmidtke, J. Biol. Chem., Jul 2006; 281: 20045 - 20054.s Kunikazu Tanji, Am. J. Pathol., Aug 2006; 169: 553 - 565. Miguel Ramalho-Santos, Science, Oct 2002; 298: 597.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total NYREN18 protein.
Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
Tissue Specificity
Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.