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Home / Primary Antibodies / IHC Antibodies

NCF2 Antibody

SKU : BHA10557170

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA015528KA01HU
Alternative Names	NCF2;FLJ93058;NCF-2;NOXA2;P67-PHOX;P67PHOX
Categories	Primary Antibodies
Description	The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558. Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease. Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure.p67phox appears to coordinate assembly of NAPDH oxidase as it associates with multiple subunits as well as the α subunit of heterotrimeric G proteins. Mutations in the corresponding p67phox gene are also associated with a form of autosomal recessive chronic granulomatous disease.
Hgnc	7661
Host	Rabbit
Immunogen	Recombinant protein of human NCF2
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive (CGD2)
Isotype	IgG
Mgi	97284
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558. Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease. Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure.p67phox appears to coordinate assembly of NAPDH oxidase as it associates with multiple subunits as well as the α subunit of heterotrimeric G proteins. Mutations in the corresponding p67phox gene are also associated with a form of autosomal recessive chronic granulomatous disease.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Cytoplasm

Rgd	1309424
Target Details	This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in two transcript variants that encode the same protein.
Uniprot	P19878
Database Links	HGNC:7661 OMIM:233710 KEGG:hsa:4688 STRING:9606.ENSP00000356505 UniGene:Hs.587558
Function	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Pathway	Leukocyte transendothelial migration Osteoclast differentiation
Protein Families	NCF2/NOXA1 family

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557170	CSB-PA015528KA01HU	100μl	$387.33		Add to Cart

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