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Home / Primary Antibodies / IHC Antibodies

NCF1 (Ab-345) Antibody

SKU : BHA10559158

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA933588
Alternative Names	47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-1; NCF-47K; NCF1
Categories	Primary Antibodies
Clonality	polyclonal
Description	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).Volpp B.D., Proc. Natl. Acad. Sci. U.S.A. 86:7195-7199(1989).Lomax K.J., Science 245:409-412(1989).Rodaway A.R.F., Mol. Cell. Biol. 10:5388-5396(1990).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human p47 phox around the phosphorylation site of serine 345 (P-Q-S(p)-P-G).
Involvement In Disease	Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive (CGD1)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Volpp B.D., Proc. Natl. Acad. Sci. U.S.A. 86:7195-7199(1989). Lomax K.J., Science 245:409-412(1989). Rodaway A.R.F., Mol. Cell. Biol. 10:5388-5396(1990).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total p47 phox protein.
Subcellular Location	Cytoplasm, cytosol, Membrane, Peripheral membrane protein, Cytoplasmic side

Uniprot	P14598
Database Links	HGNC:7660 OMIM:233700 KEGG:hsa:653361 STRING:9606.ENSP00000289473 UniGene:Hs.647047
Function	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Pathway	Chemokine signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Osteoclast differentiation
Tissue Specificity	Detected in peripheral blood monocytes and neutrophils (at protein level).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559158	CSB-PA933588	100ul	$297		Add to Cart

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