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Home / Primary Antibodies / IHC Antibodies

MRC2 Antibody

SKU : BHA10559844

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA561662
Alternative Names	Macrophage mannose receptor 2 [Precursor]; Urokinase receptor-associated protein; Endocytic receptor 180; CD280 antigen; MRC2
Categories	Primary Antibodies
Clonality	polyclonal
Description	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).Behrendt N., J. Biol. Chem. 275:1993-2002(2000).Sheikh H., J. Cell Sci. 113:1021-1032(2000).Howard M.J., J. Biol. Chem. 277:32320-32331(2002).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MRC2.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). Behrendt N., J. Biol. Chem. 275:1993-2002(2000). Sheikh H., J. Cell Sci. 113:1021-1032(2000). Howard M.J., J. Biol. Chem. 277:32320-32331(2002).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MRC2 protein.
Subcellular Location	Membrane, Single-pass type I membrane protein

Uniprot	Q9UBG0
Database Links	HGNC:16875 OMIM:612264 KEGG:hsa:9902 STRING:9606.ENSP00000307513 UniGene:Hs.7835
Function	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Tissue Specificity	Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559844	CSB-PA561662	100ul	$297		Add to Cart

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