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Home / Primary Antibodies / IHC Antibodies

MEN1 Antibody

SKU : BHA10559418

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA108807
Alternative Names	MEAI; Menin; SCG2; Wermer syndrome; Zollinger-Ellison syndrome
Categories	Primary Antibodies
Clonality	polyclonal
Description	Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression By similarity. May be involved in DNA repair.Chandrasekharappa S.C., Science 276:404-407(1997).Jin S., Cancer Res. 63:4204-4210(2003).Schnepp R.W., Cancer Res. 64:6791-6796(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MEN1.
Involvement In Disease	Familial multiple endocrine neoplasia type I (MEN1)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression By similarity. May be involved in DNA repair. Chandrasekharappa S.C., Science 276:404-407(1997). Jin S., Cancer Res. 63:4204-4210(2003). Schnepp R.W., Cancer Res. 64:6791-6796(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MEN1 protein.
Subcellular Location	Nucleus

Uniprot	O00255
Database Links	HGNC:7010 OMIM:131100 KEGG:hsa:4221 STRING:9606.ENSP00000337088 UniGene:Hs.423348
Function	Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
Tissue Specificity	Ubiquitous.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559418	CSB-PA108807	100ul	$297		Add to Cart

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