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Home / Primary Antibodies / IHC Antibodies

MCM5 Antibody

SKU : BHA10559905

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA920054
Alternative Names	CDC46; DNA replication licensing factor MCM5; minichromosome maintenance deficient protein 5;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity By similarity. Interacts with MCMBP.Robert A. Sclafani, Genetics, May 2002; 161: 47. Marylynn Snyder, PNAS, Oct 2005; 102: 14539 - 14544. Christopher J. DaFonseca, PNAS, Mar 2001; 98: 3034. Cathleen M. Lake, Genetics, Jun 2007; 10.1534
Host	Rabbit
Immunogen	Synthesized peptide derived from Human MCM5 antibody.
Involvement In Disease	Meier-Gorlin syndrome 8 (MGORS8)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity By similarity. Interacts with MCMBP. Robert A. Sclafani, Genetics, May 2002; 161: 47. Marylynn Snyder, PNAS, Oct 2005; 102: 14539 - 14544. Christopher J. DaFonseca, PNAS, Mar 2001; 98: 3034. Cathleen M. Lake, Genetics, Jun 2007; 10.1534
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MCM5 protein.
Subcellular Location	Nucleus, Cytoplasm, cytosol

Uniprot	P33992
Database Links	HGNC:6948 OMIM:602696 KEGG:hsa:4174 STRING:9606.ENSP00000216122 UniGene:Hs.517582
Function	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.
Pathway	Cell cycle
Protein Families	MCM family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559905	CSB-PA920054	100ul	$297		Add to Cart

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