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Home / Primary Antibodies / IHC Antibodies

LIG3 Antibody

SKU : BHA10557285

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA012931KA01HU
Alternative Names	LIG2; LIG3
Categories	Primary Antibodies
Description	This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Hgnc	6600
Host	Rabbit
Immunogen	Recombinant protein of human LIG3
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Isotype	IgG
Mgi	109152
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Isoform 1: Mitochondrion, Note=Contains an N-terminal mitochondrial transit peptide, SUBCELLULAR LOCATION: Isoform 2: Mitochondrion, Note=Contains an N-terminal mitochondrial transit peptide, SUBCELLULAR LOCATION: Isoform 3: Nucleus, Note=Lacks the N-terminal mitochondrial transit peptide, SUBCELLULAR LOCATION: Isoform 4: Nucleus

Rgd	1309875
Target Details	This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. This protein is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Uniprot	P49916
Database Links	HGNC:6600 OMIM:600940 KEGG:hsa:3980 STRING:9606.ENSP00000367787 UniGene:Hs.100299
Function	Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair
Pathway	DNA repair pathway
Protein Families	ATP-dependent DNA ligase family
Tissue Specificity	Testis, thymus, prostate and heart.

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557285	CSB-PA012931KA01HU	100ul	$398		Add to Cart

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