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Home / Primary Antibodies / IHC Antibodies

KRT16 Antibody

SKU : BHA10559192

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA984046
Alternative Names	Keratin type I cytoskeletal 16; Cytokeratin-16; CK-16; K16;
Categories	Primary Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.Qian Wang, J. Virol., Jan 2004; 78: 821 - 833. RD Paladini, RD Paladini, J. Cell Biol., Feb 1996; 132: 381.M.K. Shamsher, Hum. Mol. Genet., Oct 1995; 4: 1875 - 1881.Ying-Nai Wang, Mol. Pharmacol., Jan 2006; 69: 85 - 98.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human Keratin 16.
Involvement In Disease	Pachyonychia congenita 1 (PC1); Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. Qian Wang, J. Virol., Jan 2004; 78: 821 - 833. RD Paladini, RD Paladini, J. Cell Biol., Feb 1996; 132: 381. M.K. Shamsher, Hum. Mol. Genet., Oct 1995; 4: 1875 - 1881. Ying-Nai Wang, Mol. Pharmacol., Jan 2006; 69: 85 - 98.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Keratin 16 protein.

Uniprot	P08779
Database Links	HGNC:6423 OMIM:148067 KEGG:hsa:3868 STRING:9606.ENSP00000301653 UniGene:Hs.655160
Function	Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach
Pathway	Estrogen signaling pathway
Protein Families	Intermediate filament family
Tissue Specificity	Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559192	CSB-PA984046	100ul	$297		Add to Cart

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