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Home / Primary Antibodies / IHC Antibodies

IRS1 (Ab-312) Antibody

SKU : BHA10559887

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA143388
Alternative Names	Insulin receptor substrate-1; IRS-1; IRS1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit By similarity.Araki E., Diabetes 42:1041-1054(1993).Nishiyama M., Biochem. Biophys. Res. Commun. 183:280-285(1992).The MGC Project Team; Genome Res. 14:2121-2127(2004)
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human IRS-1 around the phosphorylation site of serine 312 (A-T-S(p)-P-A).
Involvement In Disease	Diabetes mellitus, non-insulin-dependent (NIDDM)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit By similarity. Araki E., Diabetes 42:1041-1054(1993). Nishiyama M., Biochem. Biophys. Res. Commun. 183:280-285(1992). The MGC Project Team; Genome Res. 14:2121-2127(2004)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total IRS-1 protein.

Uniprot	P35568
Database Links	HGNC:6125 OMIM:125853 KEGG:hsa:3667 STRING:9606.ENSP00000304895 UniGene:Hs.471508
Function	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Pathway	mTOR signaling pathway PI3K-Akt signaling pathway Autophagy Adipocytokine signaling pathway AMPK signaling cGMP-PKG signaling pathway FoxO signaling pathway Insulin signaling pathway Neurotrophin signaling pathway

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559887	CSB-PA143388	100ul	$297		Add to Cart

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