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Home / Primary Antibodies / IHC Antibodies

IL2 Antibody

SKU : BHA10557121

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA011629KA01HU
Alternative Names	IL2;IL-2;TCGF;lymphokine
Categories	Primary Antibodies
Description	IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation. IL-2 also promotes peripheral development of Treg cells. Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells. The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ and the common gamma chain, γc. IL-2 Rα binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-2Rβ is also used by IL-15. The common γc is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21. Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways.
Hgnc	6171
Host	Rabbit
Immunogen	Recombinant protein of Human IL2
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Isotype	IgG
Mgi	96621
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation. IL-2 also promotes peripheral development of Treg cells. Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells. The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ and the common gamma chain, γc. IL-2 Rα binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-2Rβ is also used by IL-15. The common γc is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21. Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Secreted

Antigen	IL2
Rgd	1311618
Target Details	This protein is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Uniprot	P60568
Database Links	HGNC:6001 OMIM:147680 KEGG:hsa:3558 STRING:9606.ENSP00000226730 UniGene:Hs.89679
Function	Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Pathway	Jak-STAT signaling pathway PI3K-Akt signaling pathway T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation
Protein Families	IL-2 family

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC, ICC

Description

ELISA ; WB ; IHC ; ICC, WB ; ELISA ; ICC ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200
ICC	1:50-1:200

Tested Application

ELISA,WB,IHC,ICC;WB:1:500-1:2000,IHC:1:50-1:200,ICC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557121	CSB-PA011629KA01HU	100μl	$387.33		Add to Cart

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