Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. HAMAP-Rule MF_00580Yue-xin Shan, J. Biol. Chem., Nov 2003; 278: 45492 - 45498.David LaVerda, Infect. Immun., Jan 2000; 68: 303 - 309.K re L. Nielsen, J. Bacteriol., Sep 1999; 181: 5871 - 5875.Kurt M. Lin, Circulation, Apr 2001; 103: 1787 - 1792.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human HSP10.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. HAMAP-Rule MF_00580
Yue-xin Shan, J. Biol. Chem., Nov 2003; 278: 45492 - 45498. David LaVerda, Infect. Immun., Jan 2000; 68: 303 - 309. K?re L. Nielsen, J. Bacteriol., Sep 1999; 181: 5871 - 5875. Kurt M. Lin, Circulation, Apr 2001; 103: 1787 - 1792.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total HSP10 protein.
Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix
Protein Families
GroES chaperonin family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.