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Home / Primary Antibodies / IHC Antibodies

HSP90AB1 (Ab-254) Antibody

SKU : BHA10559880

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA575867
Alternative Names	HS90B; HSP 84; HSP90-beta; HSP90AB1; HSPC2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.Lothar Goretzki, AACR Meeting Abstracts, Apr 2006; 2006: 468.Jean-Fran ois Louvion, Mol. Biol. Cell, Nov 1998; 9: 3071.Angelika Lueking, Mol. Cell. Proteomics, Dec 2003; 2: 1342.Jason Fontana Circ, Res., May 2002; 90: 866.
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human HSP90B around the phosphorylation site of serine 254 (V-G-S(p)-D-E).
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Lothar Goretzki, AACR Meeting Abstracts, Apr 2006; 2006: 468. Jean-Fran?ois Louvion, Mol. Biol. Cell, Nov 1998; 9: 3071. Angelika Lueking, Mol. Cell. Proteomics, Dec 2003; 2: 1342. Jason Fontana Circ, Res., May 2002; 90: 866.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total HSP90B protein.
Subcellular Location	Cytoplasm, Melanosome, Nucleus, Secreted, Cell membrane

Uniprot	P08238
Database Links	HGNC:5258 OMIM:140572 KEGG:hsa:3326 STRING:9606.ENSP00000325875 UniGene:Hs.509736
Function	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function
Pathway	Estrogen signaling pathway PI3K-Akt signaling pathway Necroptosis Protein processing in endoplasmic reticulum Antigen processing and presentation IL-17 signaling pathway NOD-like receptor signaling pathway Th17 cell differentiation
Protein Families	Heat shock protein 90 family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559880	CSB-PA575867	100ul	$297		Add to Cart

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