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Home / Primary Antibodies / IHC Antibodies

HCLS1 Antibody

SKU : BHA10557352

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA010215KA01HU
Alternative Names	HS1; HCLS1; LckBP1; p75; CTTNL
Categories	Primary Antibodies
Description	HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin. HS1 contains four cortactin repeats and a single SH3 domain. This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse. Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1. HS1 also plays an important role in platelet activation.
Hgnc	16915
Host	Rabbit
Immunogen	Recombinant protein of Human HCLS1
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Isotype	IgG
Mgi	1346319
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin. HS1 contains four cortactin repeats and a single SH3 domain. This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse. Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1. HS1 also plays an important role in platelet activation.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Membrane, Peripheral membrane protein, Cytoplasm, Mitochondrion

Antigen	HCLS1
Rgd	727960
Uniprot	P14317
Database Links	HGNC:4844 OMIM:601306 KEGG:hsa:3059 STRING:9606.ENSP00000320176 UniGene:Hs.14601
Function	Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Tissue Specificity	Expressed only in tissues and cells of hematopoietic origin.

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557352	CSB-PA010215KA01HU	100μl	$387.33		Add to Cart

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